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Solid-phase synthesis of DNA-encoded libraries via an “aldehyde explosion” strategy

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Abstract

We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves “exploding” an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.

Graphical abstract: Solid-phase synthesis of DNA-encoded libraries via an “aldehyde explosion” strategy

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Article information


Submitted
25 Feb 2020
Accepted
16 Mar 2020
First published
17 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Solid-phase synthesis of DNA-encoded libraries via an “aldehyde explosion” strategy

N. G. Paciaroni, J. M. Ndungu and T. Kodadek, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01474E

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