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Issue 36, 2020
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Beyond temperature: controlling collagen fibrillogenesis under physiological conditions via interaction with cucurbit[7]uril

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Abstract

Under physiological ionic strength and pH, temperature has long been appreciated as the only stimulus that can be applied to induce in vitro self-assembly of tropocollagen. Here, we report a second, mechanistically new control strategy that uses non-covalent and selective binding of cucurbit[7]uril, a macrocyclic cavitand, with midchain aromatic residues on the tropocollagen surface. This strategy directly demonstrates the decisive role hydrophobic interactions play in collagen fibrillogenesis. It also points the way to the temporally-controllable formation of collagen fibrils in vivo that is highly desirable, yet challenging, in some biomedical scenarios.

Graphical abstract: Beyond temperature: controlling collagen fibrillogenesis under physiological conditions via interaction with cucurbit[7]uril

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Supplementary files

Article information


Submitted
24 Feb 2020
Accepted
26 Mar 2020
First published
02 Apr 2020

Chem. Commun., 2020,56, 4946-4949
Article type
Communication

Beyond temperature: controlling collagen fibrillogenesis under physiological conditions via interaction with cucurbit[7]uril

Q. Xie, D. Hou, J. Chang, Z. Xu, Q. Zeng, Z. Wang and Y. Chen, Chem. Commun., 2020, 56, 4946
DOI: 10.1039/D0CC01444C

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