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Additive- and column-free synthesis of rigid bis-coumarins as fluorescent dyes for G-quadruplex sensing via disaggregation-induced emission

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Abstract

A novel and efficient method to synthesize rigid bis-coumarins based on the dimerization of coumarinyl aldehydes was developed. This procedure is additive- and column-free, providing a facile and environment-friendly way to prepare fluorophores. The prepared novel fluorescent bis-coumarins exhibit favorable photophysical properties with good sensitivity and selectivity towards G-quadruplexes (G4s).

Graphical abstract: Additive- and column-free synthesis of rigid bis-coumarins as fluorescent dyes for G-quadruplex sensing via disaggregation-induced emission

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Article information


Submitted
24 Feb 2020
Accepted
12 May 2020
First published
13 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Additive- and column-free synthesis of rigid bis-coumarins as fluorescent dyes for G-quadruplex sensing via disaggregation-induced emission

H. He, K. Li, K. Yu, P. Lu, M. Feng, S. Chen and X. Yu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01437K

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