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Nickel-catalyzed carboxylation of aryl iodides with lithium formate through catalytic CO recycling

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Abstract

A protocol for the Ni-catalyzed carboxylation of aryl iodides with formate has been developed with good functional group compatibility for the synthesis of a variety of aromatic carboxylic acids under mild conditions. The reaction tolerates other functionalities for cross-coupling, such as aryl bromide, aryl chloride, aryl tosylate, and aryl pinacol boronate. The reaction proceeds through a carbonylation process with in situ generated carbon monoxide in the presence of a catalytic amount of acetic anhydride and lithium formate, avoiding the use of gaseous CO. The strategy of CO recycling in catalytic amounts is critical for the success of the reaction.

Graphical abstract: Nickel-catalyzed carboxylation of aryl iodides with lithium formate through catalytic CO recycling

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Article information


Submitted
21 Feb 2020
Accepted
06 Mar 2020
First published
06 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Nickel-catalyzed carboxylation of aryl iodides with lithium formate through catalytic CO recycling

Y. Wu, M. Fu, R. Shang and Y. Fu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01363C

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