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Issue 33, 2020
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Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions

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Abstract

Mixed 2′-F-riboguanosine and 2′-F-arabinoguanosine disubstitutions of a hybrid-type G-quadruplex are found to induce a refolding into two alternative structures with different types of V-loops upon positional exchange of the two G analogs. While conformational preferences of the incorporated G surrogates fail to fully account for the observed rearrangements, additional hydrogen bonds with a fluorine acceptor are suggested to be critical determinants of the two distinct V-loop conformers imposing different tetrad polarities.

Graphical abstract: Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions

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Supplementary files

Article information


Submitted
18 Feb 2020
Accepted
15 Mar 2020
First published
17 Mar 2020

Chem. Commun., 2020,56, 4539-4542
Article type
Communication

Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions

L. Haase and K. Weisz, Chem. Commun., 2020, 56, 4539
DOI: 10.1039/D0CC01285H

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