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Generic high-capacity protein capture and release by pH control

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Abstract

Techniques for immobilization and release of proteins are of general interest but challenging to develop. Here we show a new method for high-capacity (several μg cm−2) immobilization of proteins in polyelectrolyte brushes by multivalent hydrogen bonds. Upon increasing pH, the proteins are fully released with preserved structure and activity.

Graphical abstract: Generic high-capacity protein capture and release by pH control

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Article information


Submitted
17 Feb 2020
Accepted
28 Apr 2020
First published
29 Apr 2020

This article is Open Access

Chem. Commun., 2020, Advance Article
Article type
Communication

Generic high-capacity protein capture and release by pH control

G. Ferrand-Drake del Castillo, R. L. N. Hailes, Z. Adali-Kaya, T. Robson and A. Dahlin, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01250E

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