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New fluorescent light-up quinoxalines differentiate between parallel and nonparallel G-quadruplex topologies using different excitation/emission channels

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Abstract

In this study, new fluorescent quinoxalines were developed as G4 topology-selective probes. Among them, the most promising one could light up parallel G4s at two separate excitation wavelengths, exhibiting dual-channel emission, and light up nonparallel G4s at one excitation wavelength, showing mono-channel emission.

Graphical abstract: New fluorescent light-up quinoxalines differentiate between parallel and nonparallel G-quadruplex topologies using different excitation/emission channels

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Article information


Submitted
17 Feb 2020
Accepted
19 Mar 2020
First published
19 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

New fluorescent light-up quinoxalines differentiate between parallel and nonparallel G-quadruplex topologies using different excitation/emission channels

M. Hu and X. Chen, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01242D

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