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Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction

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Abstract

Thrombin activates protease-activated receptor-1 (PAR-1) through binding to exosite I and the active site to promote tumor growth. We have developed a new class of anti-cancer glyco-peptides to target exosite I selectively without affecting the active-site-mediated coagulation activity and showed the importance of glycans for the stability and anti-cancer activity of the glyco-peptides.

Graphical abstract: Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction

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Supplementary files

Article information


Submitted
17 Feb 2020
Accepted
03 Apr 2020
First published
13 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction

Y. Chang, J. Wu, H. Yu, H. Hsu, Y. Wu, A. L. Yu, C. T. Yu and C. Wong, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01240H

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