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Issue 53, 2020
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Bifunctional phosphine ligand-enabled gold-catalyzed direct cycloisomerization of alkynyl ketones to 2,5-disubstituted furans

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Abstract

An efficient synthesis of 2,5-disubstituted furans directly from alkynyl ketones has been developed via tandem gold(I)-catalyzed isomerization of alkynyl ketones to allenyl ketones and cycloisomerization. The key to the success of this chemistry is the use of a biphenyl-2-ylphosphine ligand featuring a critical remote tertiary amino group.

Graphical abstract: Bifunctional phosphine ligand-enabled gold-catalyzed direct cycloisomerization of alkynyl ketones to 2,5-disubstituted furans

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Submitted
17 Feb 2020
Accepted
19 May 2020
First published
26 May 2020

Chem. Commun., 2020,56, 7297-7300
Article type
Communication

Bifunctional phosphine ligand-enabled gold-catalyzed direct cycloisomerization of alkynyl ketones to 2,5-disubstituted furans

X. Hu, B. Zhou, H. Jin, Y. Liu and L. Zhang, Chem. Commun., 2020, 56, 7297
DOI: 10.1039/D0CC01238F

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