Issue 47, 2020
From the journal:

Chemical Communications

An enzyme-controlled Janus nanomachine for on-command dual and sequential release†

Ana M. Pérez-Calabuig,a   Paula Díez,a   Paloma Martínez-Ruiz, ORCID logo a   Ramón Martínez-Máñez, ORCID logo bcde   Alfredo Sánchez*a  and  Reynaldo Villalonga ORCID logo *a  

* Corresponding authors

a Nanosensors and Nanomachines Group, Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Madrid 28040, Spain
E-mail: alfredos@ucm.es, rvillalonga@quim.ucm.es

b Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, Valencia 46022, Spain

c Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Valencia, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, València, Spain

d CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain

e Unidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València, IIS La Fe, Valencia, Spain

Abstract

A novel nanomachine for dual and sequential delivery of two different compounds was developed by grafting a thiol group and a pH sensitive β-cyclodextrin-based gate-like ensemble on acetylcholinesterase-modified Au–mesoporous silica Janus nanoparticles.

Graphical abstract: An enzyme-controlled Janus nanomachine for on-command dual and sequential release

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Article information

DOI
https://doi.org/10.1039/D0CC01234C
Article type
Communication
Submitted
17 Feb 2020
Accepted
29 Apr 2020
First published
29 Apr 2020

Chem. Commun., 2020,56, 6440-6443

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An enzyme-controlled Janus nanomachine for on-command dual and sequential release

A. M. Pérez-Calabuig, P. Díez, P. Martínez-Ruiz, R. Martínez-Máñez, A. Sánchez and R. Villalonga, Chem. Commun., 2020, 56, 6440 DOI: 10.1039/D0CC01234C

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