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An enzyme-controlled Janus nanomachine for on-command dual and sequential release

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Abstract

A novel nanomachine for dual and sequential delivery of two different compounds was developed by grafting a thiol group and a pH sensitive β-cyclodextrin-based gate-like ensemble on acetylcholinesterase-modified Au–mesoporous silica Janus nanoparticles.

Graphical abstract: An enzyme-controlled Janus nanomachine for on-command dual and sequential release

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Supplementary files

Article information


Submitted
17 Feb 2020
Accepted
29 Apr 2020
First published
29 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

An enzyme-controlled Janus nanomachine for on-command dual and sequential release

A. M. Pérez-Calabuig, P. Díez, P. Martínez-Ruiz, R. Martínez-Máñez, A. Sánchez and R. Villalonga, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01234C

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