Jump to main content
Jump to site search


Visible light-mediated ipso-annulation of activated alkynes: access to 3-alkylated spiro[4,5]-trienones, thiaspiro[4,5]-trienones and azaspiro[4,5]-trienones

Author affiliations

Abstract

A novel method for chemoselective difunctionalization of activated alkynes for synthesizing 3-alkylated spiro[4,5]-trienones, thiaspiro[4,5]-trienones and spirolactams has been uncovered using photoredox catalysis under visible light conditions. The rarely used tricarbonyl compounds in photoredox catalysis were used as the alkylating source. A remarkable functional group tolerance was observed, and the application of the method has been showcased by transforming tricarbonylated spirolactams to their corresponding monocarbonylated products, which are difficult to access using traditional methods.

Graphical abstract: Visible light-mediated ipso-annulation of activated alkynes: access to 3-alkylated spiro[4,5]-trienones, thiaspiro[4,5]-trienones and azaspiro[4,5]-trienones

Back to tab navigation

Supplementary files

Article information


Submitted
15 Feb 2020
Accepted
21 Sep 2020
First published
21 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Visible light-mediated ipso-annulation of activated alkynes: access to 3-alkylated spiro[4,5]-trienones, thiaspiro[4,5]-trienones and azaspiro[4,5]-trienones

S. Manna, P. K. Someswara Ashwathappa and K. R. Prabhu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01217C

Social activity

Search articles by author

Spotlight

Advertisements