Reconstruction of nano-flares based on Au–Se bonds for high-fidelity detection of RNA in living cells

Abstract

We have, for the first time, developed a Au–Se–DNA nanoprobe by upgrading the conventional Au–S bonds of nano-flares to more stable Au–Se bonds for high-fidelity imaging of target RNAs in living cells. The design concept is potentially introduced into various Au–DNA nanosensors that offer wide application prospects in research and clinical practice.