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Nitrosoarene-Catalyzed Regioselective Aromatic C–H Sulfinylation with Thiols under Aerobic Conditions

Abstract

Aromatic amines, (hetero)arenes, such as indoles and pyrroles, are regioselectively sulfinylated under mild aerobic condition using nitrosoarene as a redox-catalyst. Nitrosoarene is involved in the electron transfer process with arene to generate a crucial arene radical cation intermediate for C–H sulfinylation. The present methodology requires no directing group, can be scaled up easily and is applicable for the late-stage functionalization of drug molecules and natural products with high regioselectivity.

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Article information


Submitted
14 Feb 2020
Accepted
23 Mar 2020
First published
23 Mar 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Nitrosoarene-Catalyzed Regioselective Aromatic C–H Sulfinylation with Thiols under Aerobic Conditions

I. Chatterjee, S. Pradhan and S. Patel, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC01188F

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