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Issue 59, 2020
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Gold-catalyzed intermolecular [4+1] spiroannulation via site-selective aromatic C(sp2)–H functionalization and dearomatization of phenol derivatives

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Abstract

Herein, we have developed a novel and simple protocol to realize the C–H bond functionalization/dearomatization of naphthols and phenols with ortho-alkynylaryl-α-diazoesters under gold(I) catalysis. In this protocol, various spirocyclic molecules could be obtained in good yields with excellent chemo- and regio-selectivity and moderate to good diastereoselectivity.

Graphical abstract: Gold-catalyzed intermolecular [4+1] spiroannulation via site-selective aromatic C(sp2)–H functionalization and dearomatization of phenol derivatives

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Supplementary files

Article information


Submitted
12 Feb 2020
Accepted
19 May 2020
First published
19 May 2020

Chem. Commun., 2020,56, 8202-8205
Article type
Communication

Gold-catalyzed intermolecular [4+1] spiroannulation via site-selective aromatic C(sp2)–H functionalization and dearomatization of phenol derivatives

Y. Li, Z. Tang, J. Zhang and L. Liu, Chem. Commun., 2020, 56, 8202 DOI: 10.1039/D0CC01118E

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