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Ultrasensitive detection of microRNA using a bismuthene-enabled fluorescence quenching biosensor

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Abstract

Bismuthene, a monoelemental two-dimensional material, has shown promise in the biomedical, electronic, and energy fields due to its high carrier mobility and stability at room temperature. However, its use in biosensing applications is restricted due to its undefined quenching mechanism for dye molecules. Herein, we developed a novel ultrathin bismuthene-based sensing platform for microRNA (miRNA)-specific detection that even discriminates single-base mismatches. The detection limit can reach 60 pM. Excitingly, with the fluorescence quenching mechanism of bismuthene, ground state weakly fluorescent charge transfer is determined via femtosecond pump–probe spectroscopy. This finding provides a proof-of-concept platform to (i) fundamentally explore the quenching mechanism of bismuthene and (ii) sensitively detect miRNA molecules for early cancer.

Graphical abstract: Ultrasensitive detection of microRNA using a bismuthene-enabled fluorescence quenching biosensor

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Supplementary files

Article information


Submitted
07 Feb 2020
Accepted
12 May 2020
First published
13 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Ultrasensitive detection of microRNA using a bismuthene-enabled fluorescence quenching biosensor

T. Xue, S. R. Bongu, H. Huang, W. Liang, Y. Wang, F. Zhang, Z. Liu, Y. Zhang, H. Zhang and X. Cui, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC01004A

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