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An enzymatically self-assembled DNA patch for enhanced blood coagulation

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Abstract

DNA has been widely investigated as a carrier for drug delivery. Here, we describe a macroscopic DNA film that has been generated enzymatically. This DNA film was subsequently coated with thrombin (TB) using an aptamer–protein interaction, to expedite hemostasis over a large area. The DNA film coated with TB (DNA patch) significantly improved plasma hemostasis by acting as a coagulative scaffold for TB, as well as carrying localized TB. This study elucidates the benefits of using enzymatic amplification-based DNA structures in the context of topical drug treatment.

Graphical abstract: An enzymatically self-assembled DNA patch for enhanced blood coagulation

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Article information


Submitted
06 Feb 2020
Accepted
15 Apr 2020
First published
16 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

An enzymatically self-assembled DNA patch for enhanced blood coagulation

D. Kim, J. Kim and J. B. Lee, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00974A

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