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An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes

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Abstract

An effective and regioselective strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes was developed. By combination of TMSCnF2n+1 (n = 1, 2, 3) with PIFA, the method achieved the corresponding perfluoroalkylated products with broad functional group tolerance.

Graphical abstract: An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes

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Article information


Submitted
06 Feb 2020
Accepted
16 Jun 2020
First published
17 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes

Y. Pan, J. Li, Z. Li, F. Huang, X. Ma, W. Jiao and H. Shao, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00963F

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