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COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs

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Abstract

Herein, we report on the capacity of the amphiphilic inorganic anion cobalt bis(dicarbollide) to stabilise oil-in-water nanoemulsions (NEs). The resulting NEs show long term stability in water and high drug-loading capacity, and can prolong the residence time of hydrophobic drugs in the lungs as determined by in vivo positron emission tomography imaging.

Graphical abstract: COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs

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Article information


Submitted
04 Feb 2020
Accepted
29 Jun 2020
First published
30 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs

M. Navascuez, D. Dupin, H. Grande, V. Gómez-Vallejo, I. Loinaz, U. Cossío and J. Llop, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00918K

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