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Simultaneous imaging of lysosomal and mitochondrial viscosity during mitophagy using molecular rotors with dual-color emission

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Abstract

Two molecular rotors with a single excitation and dual-color emission wavelengths were engineered for simultaneous imaging of lysosomal and mitochondrial viscosity. These two molecular rotors were highly sensitive to viscosity without dependence on pH or polarity, facilitating simultaneous imaging of lysosomal and mitochondrial viscosity during mitophagy in living cells.

Graphical abstract: Simultaneous imaging of lysosomal and mitochondrial viscosity during mitophagy using molecular rotors with dual-color emission

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Article information


Submitted
03 Feb 2020
Accepted
04 Jun 2020
First published
04 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Simultaneous imaging of lysosomal and mitochondrial viscosity during mitophagy using molecular rotors with dual-color emission

W. Chen, J. Han, J. She, F. Wang, L. Zhu, R. Yu and J. Jiang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00868K

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