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Sporormielones A–E, bioactive novel C–C coupled orsellinic acid derivative dimers, and their biosynthetic origin

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Abstract

Sporormielones A–E (1–5), novel C–C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1–3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, 13C labelling, and gene deletion, their plausible biosynthetic mechanism was proposed.

Graphical abstract: Sporormielones A–E, bioactive novel C–C coupled orsellinic acid derivative dimers, and their biosynthetic origin

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Article information


Submitted
02 Feb 2020
Accepted
18 Mar 2020
First published
18 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Sporormielones A–E, bioactive novel C–C coupled orsellinic acid derivative dimers, and their biosynthetic origin

G. Chen, D. Hu, M. Huang, J. Tang, X. Wang, J. Zou, J. Xie, W. Zhang, L. Guo, X. Yao, I. Abe and H. Gao, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00855A

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