Sporormielones A–E, bioactive novel C–C coupled orsellinic acid derivative dimers, and their biosynthetic origin†
Abstract
Sporormielones A–E (1–5), novel C–C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1–3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, 13C labelling, and gene deletion, their plausible biosynthetic mechanism was proposed.