Jump to main content
Jump to site search


Photochemical α-carboxyalkylation of tryptophols and tryptamines via C–H functionalization

Author affiliations

Abstract

A process for the α-carboxyalkylation of tryptophols and tryptamines by the functionalization of C–H bonds under visible light irradiation has been developed. The photochemical strategy activated the C–Br bonds of α-bromo-alkylcarboxylic esters to provide carbon-centered radicals under the catalysis of Ir(III) photocatalyst and coupled with indole derivatives. This methodology displayed wide functional group tolerance and excellent regioselectivity, and was applied to the late-stage functionalization and preparation of indole-containing hybrids.

Graphical abstract: Photochemical α-carboxyalkylation of tryptophols and tryptamines via C–H functionalization

Back to tab navigation

Supplementary files

Article information


Submitted
02 Feb 2020
Accepted
18 Mar 2020
First published
19 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Photochemical α-carboxyalkylation of tryptophols and tryptamines via C–H functionalization

Z. Pan, Y. Liu, F. Hu, Q. Liu, W. Shang and C. Xia, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00847H

Social activity

Search articles by author

Spotlight

Advertisements