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Asymmetric synthesis of quaternary α-trifluoromethyl α-amino acids by Ir-catalyzed allylation followed by kinetic resolution

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Abstract

Facile access to quaternary α-trifluoromethyl α-amino acids has been developed. This sequential reaction involves an Ir-catalyzed asymmetric allylation of α-trifluoromethyl aldimine esters followed by an unprecedented kinetic resolution.

Graphical abstract: Asymmetric synthesis of quaternary α-trifluoromethyl α-amino acids by Ir-catalyzed allylation followed by kinetic resolution

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Article information


Submitted
02 Feb 2020
Accepted
11 Feb 2020
First published
13 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Asymmetric synthesis of quaternary α-trifluoromethyl α-amino acids by Ir-catalyzed allylation followed by kinetic resolution

X. Sun, Q. Ou-Yang, S. Xu, X. Wang, H. Tao, L. W. Chung and C. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00845A

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