Issue 56, 2020
From the journal:

Chemical Communications

Platinum-AIEgen coordination complex for imaging-guided annihilation of cisplatin-resistant cancer cells†

Zhenyan He,‡a   Yuting Gao,‡a   Haoke Zhang, ORCID logo b   Xiuxia Wang,a   Fanling Meng, ORCID logo a   Liang Luo ORCID logo *a  and  Ben Zhong Tang ORCID logo *b  

* Corresponding authors

a National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
E-mail: liangluo@hust.edu.cn

b Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

Abstract

We report the synthesis and comprehensive characterization of a new platinum-AIEgen coordination complex. Possessing a high 1O2 quantum yield of 0.75 in water, the complex efficiently kills cisplatin-resistant cancer cells under mild white light irradiation. Its strong fluorescence upon binding with proteins also enables direct visualization of its intracellular distribution.

Graphical abstract: Platinum-AIEgen coordination complex for imaging-guided annihilation of cisplatin-resistant cancer cells

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Article information

DOI
https://doi.org/10.1039/D0CC00821D
Article type
Communication
Submitted
01 Feb 2020
Accepted
04 Jun 2020
First published
04 Jun 2020

Chem. Commun., 2020,56, 7785-7788

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Platinum-AIEgen coordination complex for imaging-guided annihilation of cisplatin-resistant cancer cells

Z. He, Y. Gao, H. Zhang, X. Wang, F. Meng, L. Luo and B. Z. Tang, Chem. Commun., 2020, 56, 7785 DOI: 10.1039/D0CC00821D

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