Targeted imaging of integrins in cancer tissues using photocleavable Ru(II) polypyridine complexes as mass-tags

Jiaying Han; Jing Sun; Shanshan Song; Leonie Beljaars; Geny M. M. Groothuis; Hjalmar Permentier; Rainer Bischoff; Gyorgy B. Halmos; Cornelia J. Verhoeven; Erika R. Amstalden van Hove; Peter Horvatovich; Angela Casini

doi:10.1039/D0CC00774A

Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags†

Jiaying Han,^a Jing Sun,^b Shanshan Song,^a Leonie Beljaars,^a Geny M. M. Groothuis,^a Hjalmar Permentier,^a Rainer Bischoff,

^a Gyorgy B. Halmos,

^c Cornelia J. Verhoeven,

^c Erika R. Amstalden van Hove,^de Peter Horvatovich

*^a and Angela Casini

*^af

Author affiliations

* Corresponding authors

^a Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
E-mail: p.l.horvatovich@rug.nl

^b Zernike Institute for Advanced Materials, University of Groningen, The Netherlands

^c Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, The Netherlands

^d Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, Free University of Amsterdam, The Netherlands

^e ERA Advanced Analytics, Amsterdam, The Netherlands

^f Chair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching, Germany
E-mail: angela.casini@tum.de

Abstract

Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(II) polypyridine complexes as mass-tags for imaging of integrins αvβ3 in human cancer tissues.

Chemical Communications

Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags†

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Targeted imaging of integrins in cancer tissues using photocleavable Ru(II) polypyridine complexes as mass-tags

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