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Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

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Abstract

Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(II) polypyridine complexes as mass-tags for imaging of integrins αvβ3 in human cancer tissues.

Graphical abstract: Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

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Supplementary files

Article information


Submitted
30 Jan 2020
Accepted
21 Apr 2020
First published
21 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Targeted imaging of integrins in cancer tissues using photocleavable Ru(II) polypyridine complexes as mass-tags

J. Han, J. Sun, S. Song, L. Beljaars, G. M. M. Groothuis, H. Permentier, R. Bischoff, G. B. Halmos, C. J. Verhoeven, E. R. Amstalden van Hove, P. Horvatovich and A. Casini, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00774A

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