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Zinc sulfide nanoparticle-decorated fibre mesh to enable localized H2S-amplified chemotherapy

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Abstract

For the first time, we report the design and fabrication of a ZnS nanoparticle-decorated silica fibre mesh (ZnS@SiO2) for localized H2S-amplified chemotherapy. With incorporation of DOX, implanted ZnS@SiO2 fibres enable sufficient on-site drug dosage and intracellular H2S content, inducing significant in vitro and in vivo tumour inhibition.

Graphical abstract: Zinc sulfide nanoparticle-decorated fibre mesh to enable localized H2S-amplified chemotherapy

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Article information


Submitted
31 Jan 2020
Accepted
12 Mar 2020
First published
13 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Zinc sulfide nanoparticle-decorated fibre mesh to enable localized H2S-amplified chemotherapy

G. Wang, D. Cen, Z. Ren, Y. Wang, X. Cai, X. Chen, X. Li, S. Best and G. Han, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00763C

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