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Conformational impact of aliphatic side chains in local anaesthetics: benzocaine, butamben and isobutamben

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Abstract

We studied the impact of aliphatic side chains on the stability and conformational landscape of the local anaesthetics benzocaine, butamben and isobutamben, combining high-resolution rotational spectroscopy in the microwave and millimetre regions and molecular modelling. The study reveals the connections between alkyl chain flexibility and molecular conformations.

Graphical abstract: Conformational impact of aliphatic side chains in local anaesthetics: benzocaine, butamben and isobutamben

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Article information


Submitted
31 Jan 2020
Accepted
03 Apr 2020
First published
03 Apr 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Conformational impact of aliphatic side chains in local anaesthetics: benzocaine, butamben and isobutamben

A. Insausti, C. Calabrese, M. Parra, I. Usabiaga, M. Vallejo-López, P. Écija, F. J. Basterretxea, J.-U. Grabow, W. Caminati, A. Lesarri and E. J. Cocinero, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00760A

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