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Issue 45, 2020
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Conformational impact of aliphatic side chains in local anaesthetics: benzocaine, butamben and isobutamben

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Abstract

We studied the impact of aliphatic side chains on the stability and conformational landscape of the local anaesthetics benzocaine, butamben and isobutamben, combining high-resolution rotational spectroscopy in the microwave and millimetre regions and molecular modelling. The study reveals the connections between alkyl chain flexibility and molecular conformations.

Graphical abstract: Conformational impact of aliphatic side chains in local anaesthetics: benzocaine, butamben and isobutamben

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Article information


Submitted
31 Jan 2020
Accepted
03 Apr 2020
First published
03 Apr 2020

Chem. Commun., 2020,56, 6094-6097
Article type
Communication

Conformational impact of aliphatic side chains in local anaesthetics: benzocaine, butamben and isobutamben

A. Insausti, C. Calabrese, M. Parra, I. Usabiaga, M. Vallejo-López, P. Écija, F. J. Basterretxea, J.-U. Grabow, W. Caminati, A. Lesarri and E. J. Cocinero, Chem. Commun., 2020, 56, 6094
DOI: 10.1039/D0CC00760A

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