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Design of potent Mincle signalling agonists based on an alkyl β-glucoside template

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Abstract

The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure–activity relationships we design simple alkyl 6-O-acyl-β-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.

Graphical abstract: Design of potent Mincle signalling agonists based on an alkyl β-glucoside template

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Article information


Submitted
24 Jan 2020
Accepted
09 Mar 2020
First published
10 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Design of potent Mincle signalling agonists based on an alkyl β-glucoside template

D. G. M. Smith, Y. Hosono, M. Nagata, S. Yamasaki and S. J. Williams, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00670J

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