Design of potent Mincle signalling agonists based on an alkyl β-glucoside template†
Abstract
The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure–activity relationships we design simple alkyl 6-O-acyl-β-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.