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An improved tumor-specific therapeutic strategy by the spatio-temporally controlled in situ formation of a Cu(ii) complex, leading to prompt cell apoptosis via photoactivation of a prodrug

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Abstract

The anti-tumor activity of Cu complexes is well established in cancer research. We developed a biotin-tagged Cu-chelating prodrug that is activated by one-photon and two-photon irradiation for the target-specific and spatio-temporally controlled in situ generation of a Cu complex. In this way, we transform copper from a “cancer-promoting” agent to an anticancer agent.

Graphical abstract: An improved tumor-specific therapeutic strategy by the spatio-temporally controlled in situ formation of a Cu(ii) complex, leading to prompt cell apoptosis via photoactivation of a prodrug

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Article information


Submitted
24 Jan 2020
Accepted
09 Mar 2020
First published
09 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

An improved tumor-specific therapeutic strategy by the spatio-temporally controlled in situ formation of a Cu(II) complex, leading to prompt cell apoptosis via photoactivation of a prodrug

A. Chaudhuri, R. Mengji, Y. Venkatesh, A. Jana and N. D. Pradeep Singh, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00667J

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