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Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly

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Abstract

In this study, we have constructed a binary supramolecular nanoassembly composed of α-cyclodextrin-modified hyaluronic acid and an azobenzene-modified diphenylalanine derivative with a positively charged imidazole group. This nanoassembly can bind with siRNA through electrostatic interactions and efficiently delivered them into cancer cells and inhibited their growth.

Graphical abstract: Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly

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Article information


Submitted
23 Jan 2020
Accepted
28 Feb 2020
First published
28 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly

F. Li, Q. Yu, Y. Liu, H. Yu, Y. Chen and Y. Liu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00629G

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