Issue 56, 2020

The biothiol-triggered organotrisulfide-based self-immolative fluorogenic donors of hydrogen sulfide enable lysosomal trafficking

Abstract

Biothiol-reactive organotrisulfide-based self-immolative fluorogenic donors of H2S are rationally designed for the efficient monitoring of intracellular and lysosomal trafficking of H2S with a concomitant turn-on fluorescence. The non-toxic nature of the donors with a sustained release of H2S will certainly be helpful for their biomedical applications in the future.

Graphical abstract: The biothiol-triggered organotrisulfide-based self-immolative fluorogenic donors of hydrogen sulfide enable lysosomal trafficking

Supplementary files

Article information

Article type
Communication
Submitted
22 Jan 2020
Accepted
04 Jun 2020
First published
05 Jun 2020

Chem. Commun., 2020,56, 7769-7772

The biothiol-triggered organotrisulfide-based self-immolative fluorogenic donors of hydrogen sulfide enable lysosomal trafficking

S. K. Mahato, D. Bhattacherjee and K. P. Bhabak, Chem. Commun., 2020, 56, 7769 DOI: 10.1039/D0CC00613K

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