Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Synthesis of pyrazolo[1,5-c]quinazoline derivatives through the copper-catalyzed domino reaction of o-alkenyl aromatic isocyanides with diazo compounds

Author affiliations

Abstract

A novel copper-catalyzed domino reaction between o-alkenyl aromatic isocyanides and diazo compounds has been developed under mild reaction conditions. Various o-alkenyl aromatic isocyanides were prepared from readily available reactants. The reaction provides a general and efficient method for the synthesis of pyrazolo[1,5-c]quinazolines by the formation of two rings and three new bonds in a single step from readily available acyclic starting materials. A mechanism involving a tandem (3+2) cyclization/elimination/intramolecular aza-addition sequence was proposed.

Graphical abstract: Synthesis of pyrazolo[1,5-c]quinazoline derivatives through the copper-catalyzed domino reaction of o-alkenyl aromatic isocyanides with diazo compounds

Back to tab navigation

Supplementary files

Article information


Submitted
21 Jan 2020
Accepted
29 May 2020
First published
02 Jun 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Synthesis of pyrazolo[1,5-c]quinazoline derivatives through the copper-catalyzed domino reaction of o-alkenyl aromatic isocyanides with diazo compounds

L. Liu, L. Li, S. Mao, X. Wang, M. Zhou, Y. Zhao and H. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00594K

Social activity

Search articles by author

Spotlight

Advertisements