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A DNA logic gate with dual-anchored proximity aptamers for the accurate identification of circulating tumor cells

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Abstract

We have designed a DNA logic gate that can integrate the recognition of multiple biomarkers with signal amplification to perform the accurate and sensitive analysis of circulating tumor cells (CTCs). It also has the potential to analyze rare cells that exist in small amounts but are of great significance (such as stem cells) in the fields of clinical diagnosis and biomedicine.

Graphical abstract: A DNA logic gate with dual-anchored proximity aptamers for the accurate identification of circulating tumor cells

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Supplementary files

Article information


Submitted
21 Jan 2020
Accepted
04 May 2020
First published
05 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A DNA logic gate with dual-anchored proximity aptamers for the accurate identification of circulating tumor cells

T. Chen, X. Fu, Q. Zhang, D. Mao, Y. Song, C. Feng and X. Zhu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00564A

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