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Activatable fluorescent probes for hydrolase enzymes based on coumarin–hemicyanine hybrid fluorophores with large Stokes shifts

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Abstract

We show that the equilibrium of intramolecular spirocyclization of coumarin–hemicyanine hybrid fluorophores can be finely tuned by means of chemical modifications. We used this scaffold to develop activatable fluorescent probes with large Stokes shifts for γ-glutamyltranspeptidase and esterase.

Graphical abstract: Activatable fluorescent probes for hydrolase enzymes based on coumarin–hemicyanine hybrid fluorophores with large Stokes shifts

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Article information


Submitted
04 Mar 2020
Accepted
30 Mar 2020
First published
30 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Activatable fluorescent probes for hydrolase enzymes based on coumarin–hemicyanine hybrid fluorophores with large Stokes shifts

H. Fujioka, S. Uno, M. Kamiya, R. Kojima, K. Johnsson and Y. Urano, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00559B

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