Issue 28, 2020
From the journal:

Chemical Communications

Imaging and therapeutic applications of Zn(ii)-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy†

Qi-Pin Qin, ORCID logo ‡*ab   Zu-Zhuang Wei,‡c   Zhen-Feng Wang,a   Xiao-Ling Huang,a   Ming-Xiong Tan, ORCID logo a   Hua-Hong Zou ORCID logo *b  and  Hong Liang ORCID logo *b  

* Corresponding authors

a Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, P. R. China
E-mail: qpqin2018@126.com
Fax: +86-775-2623650
Tel: +86-775-2623650

b State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin 541004, P. R. China
E-mail: qpqin2018@126.com, gxnuchem@foxmail.com, hliang@mailbox.gxnu.edu.cn

c School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P. R. China

Abstract

Novel red Zn(II) complex-based fluorescent probes featuring cryptolepine–curcumin derivatives, namely, [Zn(BQ)Cl2] (BQ-Zn) and [Zn(BQ)(Cur)]Cl (BQCur-Zn), were developed for the simple and fluorescent label-free detection of apoptosis, an important biological process. The probes could synergistically promote mitochondrion-mediated apoptosis and enhance tumor therapeutic effects in vitro and vivo.

Graphical abstract: Imaging and therapeutic applications of Zn(ii)-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/D0CC00524J
Article type
Communication
Submitted
20 Jan 2020
Accepted
04 Mar 2020
First published
04 Mar 2020

Chem. Commun., 2020,56, 3999-4002

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Imaging and therapeutic applications of Zn(II)-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy

Q. Qin, Z. Wei, Z. Wang, X. Huang, M. Tan, H. Zou and H. Liang, Chem. Commun., 2020, 56, 3999 DOI: 10.1039/D0CC00524J

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