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Imaging and therapeutic applications of Zn(ii)-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy

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Abstract

Novel red Zn(II) complex-based fluorescent probes featuring cryptolepine–curcumin derivatives, namely, [Zn(BQ)Cl2] (BQ-Zn) and [Zn(BQ)(Cur)]Cl (BQCur-Zn), were developed for the simple and fluorescent label-free detection of apoptosis, an important biological process. The probes could synergistically promote mitochondrion-mediated apoptosis and enhance tumor therapeutic effects in vitro and vivo.

Graphical abstract: Imaging and therapeutic applications of Zn(ii)-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy

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Article information


Submitted
20 Jan 2020
Accepted
04 Mar 2020
First published
04 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Imaging and therapeutic applications of Zn(II)-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy

Q. Qin, Z. Wei, Z. Wang, X. Huang, M. Tan, H. Zou and H. Liang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00524J

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