Issue 42, 2020

GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy

Abstract

Herein, a promising strategy is explored to regulate redox balance in tumor cells by simultaneously consuming GSH and releasing SO2 gas for enhanced photodynamic therapy. The photosensitizer is loaded with a carrier that releases SO2 gas in response to GSH overexpressed in the cell. SO2 was found not only to induce cell apoptosis but also increase the intercellular ROS level. Meanwhile, the loaded-photosensitizers could also generate ROS with light irradiation, resulting in apoptosis or necrosis of cells.

Graphical abstract: GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
17 Jan 2020
Accepted
08 Apr 2020
First published
09 Apr 2020

Chem. Commun., 2020,56, 5645-5648

GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy

Y. Zhang, W. Shen, P. Zhang, L. Chen and C. Xiao, Chem. Commun., 2020, 56, 5645 DOI: 10.1039/D0CC00470G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements