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Nickel-catalyzed intramolecular desymmetrization addition of aryl halides to 1,3-diketones

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Abstract

A nickel-catalyzed intramolecular addition of aryl halides to 1,3-diketones was first developed. This desymmetrization reaction afforded polycyclic products bearing two tetrasubstituted centers with excellent diastereoselectivities and high yields. Moderate enantioselectivities were achieved in the presence of a chiral ligand. This transformation has great potential for the synthesis of polycyclic compounds including spiro[4,4,3,0] compounds.

Graphical abstract: Nickel-catalyzed intramolecular desymmetrization addition of aryl halides to 1,3-diketones

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Article information


Submitted
17 Jan 2020
Accepted
12 Mar 2020
First published
12 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Nickel-catalyzed intramolecular desymmetrization addition of aryl halides to 1,3-diketones

P. Zhou and T. XU, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00457J

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