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Using changes in speciation in a dynamic combinatorial library as a fingerprint to differentiate the methylation states of arginine

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Abstract

Herein we describe the development of a sensor array that utilizes the complex response of a dynamic combinatorial library (DCL) to discriminate all of the methylation states of Arg, previously unreported in a sensor array, as well as the methylation states of Lys. We find that the use of all species in the DCL, not just those that bind, allows for discrimination of analytes that are otherwise indistinguishable, demonstrating the value of utilizing a complex network of species for differential sensing.

Graphical abstract: Using changes in speciation in a dynamic combinatorial library as a fingerprint to differentiate the methylation states of arginine

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Article information


Submitted
15 Jan 2020
Accepted
03 Mar 2020
First published
03 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Using changes in speciation in a dynamic combinatorial library as a fingerprint to differentiate the methylation states of arginine

A. G. Mullins, L. E. St. Louis and M. L. Waters, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00415D

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