Jump to main content
Jump to site search


Intramolecular methionine alkylation constructs sulfonium tethered peptides for protein conjugation

Author affiliations

Abstract

Continuous efforts have been invested in the selective modification of proteins. Herein, we first report the construction of sulfonium tethered cyclic peptides via an intramolecular cyclization by an aliphatic halide. This cyclization could enhance the stability and cellular uptake of peptides. Furthermore, the sulfonium center could be recognized by cysteine in the vicinity of the protein–peptide interacting interface and form a peptide–protein conjugate.

Graphical abstract: Intramolecular methionine alkylation constructs sulfonium tethered peptides for protein conjugation

Back to tab navigation

Supplementary files

Article information


Submitted
23 Jan 2020
Accepted
22 Feb 2020
First published
24 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Intramolecular methionine alkylation constructs sulfonium tethered peptides for protein conjugation

Y. Li, C. Lian, Z. Hou, D. Wang, R. Wang, C. Wan, W. Zhong, R. Zhao, Y. Wang, S. Li, F. Yin and Z. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00377H

Social activity

Search articles by author

Spotlight

Advertisements