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Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen–host cell interactions

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Abstract

Fluorescence in vitro bioimaging suffers from photobleaching of organic dyes, thus, functional probes with superior photostability are urgently needed. Here, we address this challenge by developing novel silica-coated nanophosphors that may serve as superior luminescent nanoprobes compatible with conventional fluorescence microscopes. We specifically explore their suitability for dynamic in vitro bioimaging of interactions between bacterial pathogens and host cells, and further demonstrate the facile surface functionalization of the amorphous silica layer with antibodies for selective cell targeting.

Graphical abstract: Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen–host cell interactions

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Supplementary files

Article information


Submitted
13 Jan 2020
Accepted
12 May 2020
First published
12 May 2020

This article is Open Access

Chem. Commun., 2020, Advance Article
Article type
Communication

Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen–host cell interactions

F. Iovino, P. Merkl, A. Spyrogianni, B. Henriques-Normark and G. A. Sotiriou, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00329H

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