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Sensitive RNase A detection and intracellular imaging using natural compound-assisted tetrahedral DNA nanoprobe

Abstract

We report an intracellular imaging and assay nanoplatform for RNase A by using DNA tetrahedra-based fluorescent probe as substrate. Importantly, natural compound was used as RNase A activity stimulator to improve sensitivity in vitro and in living cells. According to our point, this platform can be widely applied for the diagnosis and prognosis of RNase A-related diseases and RNase A targeted drug screening.

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Supplementary files

Article information


Accepted
10 Feb 2020
First published
11 Feb 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Sensitive RNase A detection and intracellular imaging using natural compound-assisted tetrahedral DNA nanoprobe

C. Tong, Y. Hu, Q. Xie, T. Zhou, Y. Qin, J. Fan, B. Liu and W. Wang, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC00284D

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