Jump to main content
Jump to site search


Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides

Author affiliations

Abstract

Both the activity and regioselectivity of Phaseolus vulgaris epoxide hydrolase were remarkably improved via reshaping two substrate tunnels based on rational design. The elegant one-step enantioconvergent hydrolysis of seven rac-epoxides was achieved by single mutants, allowing green and efficient access to valuable (R)-1,2 diols with high eep (90.1–98.3%) and yields.

Graphical abstract: Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides

Back to tab navigation

Supplementary files

Article information


Submitted
11 Jan 2020
Accepted
24 Jan 2020
First published
24 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides

D. Hu, X. Zong, F. Xue, C. Li, B. Hu and M. Wu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00283F

Social activity

Search articles by author

Spotlight

Advertisements