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Cross-β amyloid nanotubes for hydrolase–peroxidase cascade reactions

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Abstract

Herein, we report the catalytic potential of short peptide based cross-β amyloid nanotubes with surface exposed histidine capable of binding hemin and showing facile cascade reactions, playing the dual roles of hydrolases and peroxidases, two of the most important classes of enzymes in extant biology. The activity of these simple systems exceeded those of modern and larger proteins like cytochrome C and hemoglobin. Further, evidence suggested that these self-assembled nanotubes foreshadow the process of intermediate channeling, a feature seen in the case of advanced enzymes.

Graphical abstract: Cross-β amyloid nanotubes for hydrolase–peroxidase cascade reactions

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Article information


Submitted
29 Jan 2020
Accepted
28 Feb 2020
First published
28 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Cross-β amyloid nanotubes for hydrolase–peroxidase cascade reactions

A. Chatterjee, S. P. Afrose, S. Ahmed, A. Venugopal and D. Das, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00279H

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