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Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

Abstract

Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified.

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Article information


Submitted
10 Jan 2020
Accepted
25 Mar 2020
First published
25 Mar 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

C. D. Braganza, C. Motozono, K. Sonoda, S. Yamasaki, K. Shibata, M. S. M. Timmer and B. L. Stocker, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC00247J

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