Issue 14, 2020
From the journal:

Chemical Communications

Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR†

Fei Wang,‡ab   Chunxi Wang,‡ab   Yaping Liu,ab   Wenxian Lan,ab   Hao Han,c   Renxiao Wang,ab   Shaohua Huangc  and  Chunyang Cao ORCID logo *abc  

* Corresponding authors

a State Key Laboratory of Bioorganic and Natural Product Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, China
E-mail: ccao@mail.sioc.ac.cn
Tel: +86-21-54925491

b University of Chinese Academy of Science, No. 19A, Yuquan Road, Shijingshan District, Beijing, China

c Institute of Drug Discovery Technology, Ningbo University, No. 818 Fenghua Road, Ningbo, Zhejiang, China

Abstract

G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.

Graphical abstract: Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR

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Article information

DOI
https://doi.org/10.1039/D0CC00221F
Article type
Communication
Submitted
11 Jan 2020
Accepted
24 Jan 2020
First published
27 Jan 2020

Chem. Commun., 2020,56, 2099-2102

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Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR

F. Wang, C. Wang, Y. Liu, W. Lan, H. Han, R. Wang, S. Huang and C. Cao, Chem. Commun., 2020, 56, 2099 DOI: 10.1039/D0CC00221F

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