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Cisplatin binds to the MDM2 RING finger domain and inhibits the ubiquitination activity

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Abstract

Cisplatin can directly bind to the RING finger domain of MDM2, leading to the zinc-release and protein unfolding. Consequently, cisplatin inhibits the MDM2-mediated ubiquitination, which is the molecular basis of p53 activation. This work provides insight into the cisplatin-induced p53-elevation that is involved in cell apoptosis.

Graphical abstract: Cisplatin binds to the MDM2 RING finger domain and inhibits the ubiquitination activity

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Article information


Submitted
09 Jan 2020
Accepted
16 Mar 2020
First published
16 Mar 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Cisplatin binds to the MDM2 RING finger domain and inhibits the ubiquitination activity

K. Cao, X. Ding, Y. Sheng, Y. Wang and Y. Liu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00203H

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