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Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure

Abstract

The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.

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Article information


Accepted
09 Feb 2020
First published
10 Feb 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure

A. R. Araújo, S. Camero, P. Taboada, R. L. Reis and R. A. Pires, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC00192A

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