Jump to main content
Jump to site search


Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure

Author affiliations

Abstract

The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.

Graphical abstract: Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure

Back to tab navigation

Supplementary files

Article information


Submitted
08 Jan 2020
Accepted
09 Feb 2020
First published
10 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers through the remodelling of its secondary structure

A. R. Araújo, S. Camero, P. Taboada, R. L. Reis and R. A. Pires, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC00192A

Social activity

Search articles by author

Spotlight

Advertisements